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Nat Neurosci. 2005 Jan;8(1):20-1. Epub 2004 Dec 12.

Amygdala-prefrontal coupling depends on a genetic variation of the serotonin transporter.

Author information

1
Department of Psychiatry, Charité University Medicine Berlin, Campus Charité Mitte, Schumannstr. 20-21, 10117 Berlin, Germany. andreas.heinze@charite.de

Abstract

Major depression is conditionally linked to a polymorphism of the human serotonin transporter gene (SLC6A4). During the presentation of aversive, but not pleasant, pictures, healthy carriers of the SLC6A4 short (s) allele showed stronger activation of the amygdala on functional magnetic resonance imaging. s carriers also showed greater coupling between the amygdala and the ventromedial prefrontal cortex, which may contribute to the abnormally high activity in the amygdala and medial prefrontal cortex seen in major depression.

PMID:
15592465
DOI:
10.1038/nn1366
[Indexed for MEDLINE]

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