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Microbiol Mol Biol Rev. 2004 Dec;68(4):796-813.

Little lambda, who made thee?

Author information

1
Institute of Cancer Research, Columbia University, New York, NY 10032, USA. gottesman@cuccfa.ccc.columbia.edu

Abstract

The study of the bacteriophage lambda has been critical to the discipline of molecular biology. It was the source of key discoveries in the mechanisms of, among other processes, gene regulation, recombination, and transcription initiation and termination. We trace here the events surrounding these findings and draw on the recollections of the participants. We show how a particular atmosphere of interactions among creative scientists yielded spectacular insights into how living things work.

PMID:
15590784
PMCID:
PMC539004
DOI:
10.1128/MMBR.68.4.796-813.2004
[Indexed for MEDLINE]
Free PMC Article

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