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Curr Eye Res. 2004 Oct-Nov;29(4-5):269-75.

Susceptibility of aged mice to Staphylococcus aureus keratitis.

Author information

1
Department of Microbiology, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA.

Abstract

PURPOSE:

To determine the effect of age on the extent of pathogenesis of Staphylococcus keratitis in the mouse.

METHODS:

Corneas of young and aged mice (BALB/c, A/J, and C57BL/6) were scarified and topically inoculated with S. aureus. Slit lamp examination (SLE) and histopathology were performed, and bacterial colony forming units and myeloperoxidase activity were determined.

RESULTS:

SLE scores of infected eyes of aged mice were significantly higher at days 1 and 3 postinfection (PI) as compared to infected young mice. Histopathological changes observed in all aged mice were more severe than those in young mice. Young BALB/c and A/J mice demonstrated minimal signs of keratitis by day 3 PI, whereas aged mice of both strains demonstrated severe keratitis by day 3. Young C57BL/6 mice showed no clinical signs of keratitis, whereas aged C57BL/6 mice demonstrated moderate keratitis.

CONCLUSIONS:

Aged mice with S. aureus keratitis demonstrated increased pathology as compared to young mice.

PMID:
15590472
DOI:
10.1080/02713680490516783
[Indexed for MEDLINE]

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