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DNA Repair (Amst). 2005 Feb 3;4(2):279-83.

How are specialized (low-fidelity) eukaryotic polymerases selected and switched with high-fidelity polymerases during translesion DNA synthesis?

Author information

1
Laboratory of Molecular Pathology, Department of Pathology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390-9072, USA. paula.fischhaber@utsouthwestern.edu

Abstract

Specialized DNA polymerases are required in both prokaryotic and eukaryotic cells for bypassing sites of template DNA damage that arrest high-fidelity DNA replication. Recent studies in the literature provide hints of the complexity of DNA switching between polymerases for translesion DNA synthesis (TLS) and those for normal DNA replication.

PMID:
15590336
DOI:
10.1016/j.dnarep.2004.08.011
[Indexed for MEDLINE]

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