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Biochim Biophys Acta. 2004 Dec 6;1742(1-3):119-31.

Calcium and mitochondria: mechanisms and functions of a troubled relationship.

Author information

1
Department of Experimental and Diagnostic Medicine and Interdisciplinary Center for the Study of Inflammation, University of Ferrara, 44100 Ferrara, Italy.

Abstract

Mitochondria promptly respond to Ca(2+)-mediated cell stimulations with a rapid accumulation of the cation into the matrix. In this article, we review (i) the basic principles of mitochondrial Ca(2+) transport, (ii) the physiological/pathological role of mitochondrial Ca(2+) uptake, (iii) the regulatory mechanisms that may operate in vivo, and (iv) the new targeted Ca(2+) probes that allowed the "rediscovery" of these organelles in calcium signalling.

PMID:
15590062
DOI:
10.1016/j.bbamcr.2004.09.015
[Indexed for MEDLINE]
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