Chlamydia trachomatis and Human papillomavirus infections in cervical disease in Argentine women

Gynecol Oncol. 2005 Jan;96(1):181-6. doi: 10.1016/j.ygyno.2004.09.037.

Abstract

Objectives: To examine the prevalence of Human papillomavirus and Chlamydia trachomatis DNA in cervical samples among women with normal and abnormal cervical cytology from La Plata, Argentina.

Methods: Two hundred and seventy-nine women (200 with cervical neoplasia or ICC and 79 women with normal cytology) provided cervical samples for the detection of HPV and C. trachomatis DNA by PCR-based assays.

Results: HPV DNA increased with the cervical lesion severity, ranging from 30% among women with normal cytology to 99-100% among women with HSIL or ICC. C. trachomatis DNA prevalence increased from low levels in women with normal cytology (11%) to 47% in those with HSIL, but was uncommon among ICC patients (20%). Among women with normal cytology, C. trachomatis prevalence was higher in HPV DNA positive (12.5%) than HPV DNA negative women (10.9%), but this difference was not significant.

Conclusions: HPV prevalence in the general population is slightly higher than those reported for other developing countries. C. trachomatis DNA positivity was associated with a higher risk of both LSIL and HSIL lesions, but not with ICC.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Argentina / epidemiology
  • Chlamydia Infections / epidemiology*
  • Chlamydia Infections / microbiology
  • Chlamydia trachomatis / genetics*
  • DNA, Viral / analysis
  • Female
  • Humans
  • Middle Aged
  • Papillomaviridae / genetics*
  • Papillomavirus Infections / epidemiology*
  • Papillomavirus Infections / virology
  • Polymerase Chain Reaction
  • Uterine Cervical Diseases / epidemiology*
  • Uterine Cervical Diseases / microbiology*
  • Uterine Cervical Diseases / virology
  • Uterine Cervical Dysplasia / epidemiology
  • Uterine Cervical Dysplasia / microbiology
  • Uterine Cervical Dysplasia / virology
  • Uterine Cervical Neoplasms / epidemiology
  • Uterine Cervical Neoplasms / microbiology
  • Uterine Cervical Neoplasms / virology

Substances

  • DNA, Viral