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Crit Rev Immunol. 2004;24(4):229-37.

Negative regulation of T-cell function by PD-1.

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University of Chicago, Department of Pathology, Section of Hematology/Oncology, Chicago, IL 60637, USA.


PD-1 is a receptor inducibly expressed on CD4+ and CD8+ T cells following activation. PD-1-deficient mice develop signs of autoimmunity, suggesting a negative regulatory role for PD-1 in dampening lymphocyte responses. The expression of one ligand for PD-1, designated PD-L1 or B7-H1, on tumor cells of a variety of histologies has suggested a potential mechanism for tumor escape from immune destruction. This review summarizes data regarding PD-1 and related negative regulatory receptors, focusing on implications for potentiating antitumor immunity in vivo.

[Indexed for MEDLINE]

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