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J Med Chem. 2004 Dec 16;47(26):6443-6.

The design and enzyme-bound crystal structure of indoline based peptidomimetic inhibitors of hepatitis C virus NS3 protease.

Author information

1
IRBM-MRL Rome, Via Pontina km 30,600, 00040 Rome, Italy.

Abstract

The design of a series of peptidomimetic inhibitors of the hepatitis C virus NS3 protease is described. These inhibitors feature an indoline-2-carboxamide as a novel heterocyclic replacement for the P3 amino acid residue and N-terminal capping group of tripeptide based inhibitors. The crystal structure of the ternary NS3/NS4A/inhibitor complex for the most active molecule in this series highlights its suitability as an N-terminal capping group of a dipeptide inhibitor of the NS3 protease.

PMID:
15588076
DOI:
10.1021/jm049435d
[Indexed for MEDLINE]

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