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Curr Opin Cell Biol. 1992 Feb;4(1):99-104.

Intermediate filament dynamics.

Author information

1
Department of Cell, Molecular and Structural Biology, Northwestern University Medical School, Chicago, Illinois 60611-3008.

Abstract

The view of intermediate filaments as static cytoskeletal elements is changing. Studies of exogenous intermediate filament proteins, either microinjected or expressed from transfected genes, have demonstrated that a continuous incorporation of subunits into the polymerized filaments is taking place. This incorporation appears to be required for maintaining normal cytoplasmic networks of intermediate filaments. At the post-translational level, phosphorylation is an important factor in regulating dynamic aspects of intermediate filament organization and structure.

PMID:
1558758
DOI:
10.1016/0955-0674(92)90065-k
[Indexed for MEDLINE]

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