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Methods Mol Med. 2005;109:71-82.

Generation of clinical-grade monocyte-derived dendritic cells using the CliniMACS system.

Author information

1
Department of Urology, University of Innsbruck, Innsbruck, Austria.

Abstract

We describe the generation of monocyte-derived dendritic cells (MoDC) from leukapheresis products using the CliniMACS system from Miltenyi Biotec. In a clinical setting, the method turned out to be feasible for the generation of clinical-grade MoDC from patients with metastatic renal-cell carcinoma. MoDC generated with this system exhibited a fully mature phenotype as well as high migratory and T-cell stimulatory capacity.

PMID:
15585914
DOI:
10.1385/1-59259-862-5:071
[Indexed for MEDLINE]

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