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Methods Mol Med. 2005;109:1-18.

Exploiting dendritic cells for active immunotherapy of cancer and chronic infection.

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Tumor Vaccine Center, NYU Cancer Institute, New York University School of Medicine, New York, NY, USA.


Dendritic cells (DC) are important antigen-presenting cells (APC) that can prime naive T-cells and control lymphocyte-mediated adaptive immune responses with respect to magnitude, memory, and self-tolerance. Understanding the biology of these cells is central to the development of new generation immunotherapies for cancer and chronic infection. This chapter presents a brief overview of DC biology and the preparation and use of DC-based vaccines.

[Indexed for MEDLINE]

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