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Pharmacotherapy. 2004 Dec;24(12 Pt 2):203S-15S.

Resistance to antimicrobial agents: an update.

Author information

1
Anti-Infective Research Laboratory, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, Michigan 48201, USA. m.rybak@wayne.edu

Abstract

Decades of overuse and misuse of antibiotics have turned the resistance problem into a crisis. Preventive and corrective measures are urgently needed. This article presents a broad overview of the status of antimicrobial resistance. Resistance in key bacterial pathogens such as enterococci, staphylococci, pneumococci, and gram-negative bacilli; resistance to fluoroquinolones, third-generation cephalosporins, and the carbapenems; and mechanisms of resistance are discussed. The article also reviews the adverse impact of resistance on outcomes for patients with nosocomial infections. Finally, a brief overview of how the medical community can face its moment of truth is presented.

PMID:
15585450
DOI:
10.1592/phco.24.18.203S.52236
[Indexed for MEDLINE]

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