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Pharmacotherapy. 2004 Dec;24(12 Pt 2):203S-15S.

Resistance to antimicrobial agents: an update.

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Anti-Infective Research Laboratory, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, Michigan 48201, USA.


Decades of overuse and misuse of antibiotics have turned the resistance problem into a crisis. Preventive and corrective measures are urgently needed. This article presents a broad overview of the status of antimicrobial resistance. Resistance in key bacterial pathogens such as enterococci, staphylococci, pneumococci, and gram-negative bacilli; resistance to fluoroquinolones, third-generation cephalosporins, and the carbapenems; and mechanisms of resistance are discussed. The article also reviews the adverse impact of resistance on outcomes for patients with nosocomial infections. Finally, a brief overview of how the medical community can face its moment of truth is presented.

[Indexed for MEDLINE]

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