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J Am Acad Dermatol. 2004 Dec;51(6):919-22.

Chronic stress accelerates ultraviolet-induced cutaneous carcinogenesis.

Author information

1
Department of Dermatology, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA.

Abstract

BACKGROUND:

Physical and emotional stressors have been found to mediate a wide variety of biological changes including the facilitation of tumor progression; however most of these paradigms utilized artificial sources of neoplasms and stress.

METHODS:

Skh mice were exposed to carcinogenic doses of ultraviolet light (UV). The stressed group was subjected to the close proximity of fox urine as a source of stress from the presence of the odor of their natural predator, while the control group remained stress free.

RESULTS:

A significant acceleration in the development of cutaneous neoplasms was observed in mice that had been exposed to the stressor. The first tumor appeared in the group after 8 weeks, whereas nonstressed mice began to develop these by week 21.

CONCLUSION:

These results suggest that stress plays a role in potentiating cutaneous carcinogenesis.

PMID:
15583583
DOI:
10.1016/j.jaad.2004.08.042
[Indexed for MEDLINE]
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