Format

Send to

Choose Destination
J Am Acad Dermatol. 2004 Dec;51(6):899-905.

Atopic dermatitis, stinging, and effects of chronic stress: a pathocausal study.

Author information

1
Unit of Dermatology and Venereology, Department of Medicine, Karolinska Hospital, Stockholm, Sweden. sol-britt.lonne-rahm@kus.se

Abstract

BACKGROUND:

Patients with atopic dermatitis (AD) often have increased skin sensitivity and this symptom often worsens during stress.

OBJECTIVE:

We sought to find out whether patients with AD had stinging, and to identify the pathocausal neuroimmune mechanisms, including the role of stress.

METHODS:

In all, 25 patients with AD with histories of stress worsening were tested using a stinger test. Skin biopsy specimens were processed for immunohistochemistry. Stress inquiries and salivary cortisol tests were performed.

RESULTS:

In all, 16 patients were stinger-positive and 9 were negative. The stinger-positive papillary dermis had an increased number of mast cells, vasoactive intestinal polypeptide-positive fibers, and a tendency to a higher number of substance P-positive nerve fibers, but a decrease of calcitonin gene-related peptide fibers. Patients who were stinger-positive had a tendency to lower salivary cortisol.

CONCLUSIONS:

The majority of patients with AD experience stinging. Substance P, calcitonin gene-related peptide, vasoactive intestinal polypeptide, and mast cells may have a pathocausal role, as might chronic stress.

PMID:
15583580
DOI:
10.1016/j.jaad.2004.05.035
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center