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J Clin Microbiol. 2004 Dec;42(12):5861-5.

High permissivity of human HepG2 hepatoma cells for influenza viruses.

Author information

1
INSERM U526-Laboratoire de Virologie, Faculté de Médecine, avenue de Valombrose, 06107 Nice cedex 2, France. lefebvre@unice.fr.

Abstract

Human HepG2 hepatoma cells are highly permissive for influenza virus type A and type B, even without the addition of trypsin, and they exhibit a marked cytopathic effect. This property greatly facilitates the primary isolation of influenza viruses. Virus replication was significantly reduced by the plasmin(ogen)-specific inhibitor tranexamic acid, and this suggests a potential role played by the plasminogen/tissue plasminogen activator complex at the surface of HepG2 cells. This might represent a new approach for study of the interrelations of this complex with influenza viruses.

PMID:
15583326
PMCID:
PMC535305
DOI:
10.1128/JCM.42.12.5861-5865.2004
[Indexed for MEDLINE]
Free PMC Article

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