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Regul Pept. 2005 Feb 15;125(1-3):173-7.

Glucagon-like peptide-1 relaxes rat conduit arteries via an endothelium-independent mechanism.

Author information

1
Karolinska Institutet, Department of Internal Medicine, Stockholm South Hospital SE-118 83 Stockholm, Sweden. thomas.nystrom@sos.sll.se

Abstract

A lot of interest has engendered in glucagon-like peptide-1 (GLP-1) as an emerging new drug in the treatment of type 2 diabetes. GLP-1 exerts several effects that reduce glycemia in type 2 diabetes patients. We recently also demonstrated that GLP-1 ameliorates endothelial dysfunction in type 2 diabetes mellitus patients with established coronary heart disease, suggesting a new important cardioprotective role for GLP-1. Because hypertension is overrepresented in diabetes and is adversely influencing survival, we have now investigated direct GLP-1 effects on vascular beds in a rat organ bath model. It was found that GLP-1 relaxed femoral artery rings in a dose-response manner. The relaxant effect from GLP-1 was completely inhibited by the specific GLP-1 receptor antagonist, exendin(9-39). Neither the specific nitric oxide (NO) synthase inhibitor, N-nitro-L-arginine, nor removing of endothelium, affected the GLP-1 relaxant effect. In conclusion, we now report a direct vascular action of GLP-1, relaxing conduit vessels independently of NO and the endothelium.

PMID:
15582729
DOI:
10.1016/j.regpep.2004.08.024
[Indexed for MEDLINE]

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