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Int J Tuberc Lung Dis. 2004 Nov;8(11):1382-4.

Adverse events in the treatment of multidrug-resistant tuberculosis: results from the DOTS-Plus initiative.

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Stop TB Department, World Health Organization, Geneva, Switzerland.


Adverse events associated with second-line drugs have been mentioned as obstacles in the management of multidrug-resistant tuberculosis (MDR-TB). Data on adverse events were collected from five DOTS-Plus sites in Estonia, Latvia, Peru (Lima), the Philippines (Manila) and the Russian Federation (Tomsk Oblast). The results show that among 818 patients enrolled on MDR-TB treatment only 2% of patients stopped treatment, but 30% required removal of the suspected drug(s) from the regimen due to adverse events. The study shows that adverse events are manageable in the treatment of MDR-TB in resource-limited settings provided that standard management strategies are applied.

[Indexed for MEDLINE]

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