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MAGMA. 2004 Dec;17(3-6):313-6. Epub 2004 Dec 1.

Vessel size imaging using low intravascular contrast agent concentrations.

Author information

1
IFR1, Unité IRM 3T, Centre Hospitalier Universitaire, 38043, Grenoble CEDEX 9, France. Irene.Tropres@ujf-grenoble.fr

Abstract

Vessel size index (VSI) measurements have been validated on rats bearing a glioma with high doses of contrast agent. The aim of this study was to evaluate the impact of using a reduced dose of contrast agent, necessary for clinical trials. Experiments were performed on rats at three doses of AMI-227 and clearly show higher VSI values at lower doses, whatever the region of interest (contralateral, peritumoral and intratumoral tissue). These results are in good correlation with Monte-Carlo simulations on healthy brain and suggest that only relative values can be obtained at clinical contrast agent doses and magnetic fields.

PMID:
15580376
DOI:
10.1007/s10334-004-0067-3
[Indexed for MEDLINE]

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