Send to

Choose Destination
MAGMA. 2004 Dec;17(3-6):313-6. Epub 2004 Dec 1.

Vessel size imaging using low intravascular contrast agent concentrations.

Author information

IFR1, Unité IRM 3T, Centre Hospitalier Universitaire, 38043, Grenoble CEDEX 9, France.


Vessel size index (VSI) measurements have been validated on rats bearing a glioma with high doses of contrast agent. The aim of this study was to evaluate the impact of using a reduced dose of contrast agent, necessary for clinical trials. Experiments were performed on rats at three doses of AMI-227 and clearly show higher VSI values at lower doses, whatever the region of interest (contralateral, peritumoral and intratumoral tissue). These results are in good correlation with Monte-Carlo simulations on healthy brain and suggest that only relative values can be obtained at clinical contrast agent doses and magnetic fields.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Springer
Loading ...
Support Center