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Clin Infect Dis. 2004 Dec 1;39(11):1709-12. Epub 2004 Nov 9.

Determinants of immune reconstitution inflammatory syndrome in HIV type 1-infected patients with tuberculosis after initiation of antiretroviral therapy.

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Department of Infectious and Tropical Diseases, INSERM E0357, Bichat-Claude Bernard Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France.


Immune reconstitution inflammatory syndrome (IRIS) occurred in 16 of 37 antiretroviral-naive patients who were treated subsequently for tuberculosis and human immunodeficiency virus (HIV) type 1 infection. IRIS was related to increases in the CD4 cell percentage and in the ratio of CD4 cells to CD8 cells after 1 month of antiretroviral therapy and to dissemination of tuberculosis. These results have implications for the diagnosis of IRIS and the understanding of its pathogenesis.

[Indexed for MEDLINE]

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