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J Perinatol. 2005 Mar;25(3):210-5.

Risk factors for adverse neurodevelopment in extremely low birth weight infants with normal neonatal cranial ultrasound.

Author information

1
Department of Neonatal Medicine, Royal North Shore Hospital, Sydney.

Abstract

OBJECTIVES:

To determine risk factors associated with adverse developmental outcome at 5 years in extremely low birth weight infants or extremely premature infants (<28 weeks) with normal neonatal cranial ultrasounds.

DESIGN/METHODS:

Data were collected prospectively on 152 infants with gestation <28 weeks or birth-weight <1000 g. Infants were grouped into those with normal development, mild-to-moderate impairment (IQ 70 to 84, or hearing loss 30 to 89 dB, visual acuity 6/18 to 6/60, or mild/moderate cerebral palsy (CP)) and severe impairment (IQ <70, hearing loss > or =90 dB, visual acuity <6/60, or severe CP).

RESULTS:

Five-year outcomes were available for 144/152 children (95%). In all, 89 (62%) infants had normal development, 39 (27%) had mild-moderate impairment and 16 (11%) had severe impairment. On multivariate logistic regression analysis, factors associated with developmental impairment were serum bilirubin > or =200 micromol/l (odds ratio (OR) - 4.06, p=0.003) and retinopathy of prematurity (ROP) (OR - 1.6, p=0.03).

CONCLUSIONS:

A serum bilirubin > or =200 micromol/l and presence of ROP are postnatal risk factors associated with an adverse developmental outcome in infants with normal cranial ultrasounds.

PMID:
15578032
DOI:
10.1038/sj.jp.7211228
[Indexed for MEDLINE]

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