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EMBO Rep. 2004 Dec;5(12):1142-7.

Survival of protozoan intracellular parasites in host cells.

Author information

1
Instituto Gulbenkian de Ciência, Rua da Quinta Grande 6, 2780-156 Oeiras, Portugal.

Abstract

The most common human diseases are caused by pathogens. Several of these microorganisms have developed efficient ways in which to exploit host molecules, along with molecular pathways to ensure their survival, differentiation and replication in host cells. Although the contribution of the host cell to the development of many intracellular pathogens (particularly viruses and bacteria) has been unequivocally established, the study of host-cell requirements during the life cycle of protozoan parasites is still in its infancy. In this review, we aim to provide some insight into the manipulation of the host cell by parasites through discussing the hurdles that are faced by the latter during infection.

PMID:
15577928
PMCID:
PMC1299194
DOI:
10.1038/sj.embor.7400299
[Indexed for MEDLINE]
Free PMC Article

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