Format

Send to

Choose Destination
Toxicon. 1992 Feb;30(2):161-9.

In vivo and in vitro toxicity of phospholipase C from Pseudomonas aeruginosa.

Author information

1
Department of Immunology/Microbiology, Wayne State University School of Medicine, Detroit, MI 48201.

Abstract

Pseudomonas aeruginosa produces phospholipase C (PLC), a heat-labile hemolysin. Histopathological analysis of PLC-treated mice revealed that the primary target organs involved in PLC-induced toxicity were the liver and kidney. Mice treated i.v. with PLC demonstrated significant tubular epithelial necrosis of the kidney with hematuria, while when given i.p. they exhibited hepatonecrosis with cellular infiltration. Splenomegaly was also a consistent finding. Results from in vitro studies indicate that PLC is toxic for mouse peritoneal cells and human leukocytes.

PMID:
1557786
DOI:
10.1016/0041-0101(92)90469-l
[Indexed for MEDLINE]

Supplemental Content

Loading ...
Support Center