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Clin Calcium. 2004 Jul;14(7):76-8.

[BMP and LMP-1 for intervertebral disc regeneration].

[Article in Japanese]

Author information

1
Department of Orthopaedic Surgery, Kurume University School of Medicine.

Abstract

Some evidence indicates that intervertebral disc degeneration is associated with decreasing of matrix synthesis from disc cell. BMP-2 increased mRNA of aggrecan and Type II collagen. It also enhanced disc matrix (proteoglycan) production. Adenovirually mediated LMP-1 overexpression in intervertebral disc cells increased disc cell proteoglycan production through BMP-2 and BMP-7 mediated process.

PMID:
15577080
DOI:
CliCa040710961098
[Indexed for MEDLINE]
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