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Clin Calcium. 2004 Jul;14(7):58-63.

[Proteoglycan knock-out mice and osteoarthritis].

[Article in Japanese]

Author information

1
Tissue Regeneration, Department of Hard Tissue Engineering, Tokyo Medical and Dental University.

Abstract

There are several types of small leucine-rich proteoglycans expressed in articular cartilage and its surrounding tissues. Many of these proteoglycans are functioning as a modulator of collagen fibrillogenesis via binding to the surface of collagen fibers. Therefore, deficiencies of their expression in knock-out mice often result in the formation of abnormal collagen fibers leading to the instability of the join, and finally trigger osteoarthritis.

PMID:
15577077
DOI:
CliCa040710781083
[Indexed for MEDLINE]

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