Format

Send to

Choose Destination
Org Lett. 2004 Dec 9;6(25):4735-8.

Expanding the Hoogsteen edge of 2'-deoxyguanosine: consequences for G-quadruplex formation.

Author information

1
Department of Chemistry, University of Puerto Rico, Río Piedras Campus, Río Piedras, Puerto Rico 00931.

Abstract

[structure: see text] The synthesis and self-assembling properties of 8-aryl-2'-deoxyguanosine derivatives are described. Our studies suggest that a properly placed acetyl group can increase the stability and specificity of the resulting G-quadruplex supramolecules by enhancing noncovalent interactions such as hydrogen bonds and pi-stacking.

PMID:
15575673
DOI:
10.1021/ol048013v
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for American Chemical Society
Loading ...
Support Center