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Nat Rev Mol Cell Biol. 2004 Dec;5(12):1038-43.

The DNA-polymerase-X family: controllers of DNA quality?

Author information

1
Institute of Veterinary Biochemistry and Molecular Biology, University of Zürich, Winterthurerstrasse 190, CH 8057 Zürich, Switzerland.

Abstract

Synthesis of the genetic material of the cell is achieved by a large number of DNA polymerases. Besides replicating the genome, they are involved in DNA-repair processes. Recent studies have indicated that certain DNA-polymerase-X-family members can synthesize unusual DNA structures, and we propose that these DNA structures might serve as 'flag wavers' for the induction of DNA-repair and/or DNA-damage-checkpoint pathways.

PMID:
15573140
DOI:
10.1038/nrm1530
[Indexed for MEDLINE]

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