Format

Send to

Choose Destination
Nat Rev Mol Cell Biol. 2004 Dec;5(12):959-70.

AKAP signalling complexes: focal points in space and time.

Author information

1
Howard Hughes Medical Institute/Vollum Institute, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, L-474, Portland, Oregon 97239, USA.

Abstract

Multiprotein signalling networks create focal points of enzyme activity that disseminate the intracellular action of many hormones and neurotransmitters. Accordingly, the spatio-temporal activation of protein kinases and phosphatases is an important factor in controlling where and when phosphorylation events occur. Anchoring proteins provide a molecular framework that orients these enzymes towards selected substrates. A-kinase anchoring proteins (AKAPs) are signal-organizing molecules that compartmentalize various enzymes that are regulated by second messengers.

PMID:
15573134
DOI:
10.1038/nrm1527
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Nature Publishing Group
Loading ...
Support Center