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Nat Rev Immunol. 2004 Dec;4(12):931-40.

Consequences of regulated pre-mRNA splicing in the immune system.

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Department of Biochemistry, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines boulevard, Dallas, Texas 75390-9038, USA.


Alternative splicing is widely recognized to be a ubiquitous and crucial mechanism for generating protein diversity and regulating protein expression. Numerous immunologically relevant genes have been found to undergo alternative splicing; however, there has been little effort to develop a coherent picture of how alternative splicing might be used as a general mechanism to regulate the function of the immune system. In this review, I summarize the mechanisms by which splicing is controlled in T cells, and discuss the role of alternative splicing and alternative isoform expression in the regulation of T-cell activation and function.

[Indexed for MEDLINE]

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