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Nat Cell Biol. 2004 Dec;6(12):1245-6.

Intra-nuclear microtubules and a mitotic spindle orientation checkpoint.

Author information

1
Department of Microbiology, Columbia University College of Physicians and Surgeons, 701 West 168th Street, New York, NY 10032, USA.

Abstract

Cells of the fission yeast Schizosaccharomyces pombe have a checkpoint mechanism that reportedly monitors the orientation of the mitotic spindle. Astral microtubules in pre-anaphase spindles are thought to contact the contractile actin ring at the plasma membrane in order to rotate the spindle and to sense spindle orientation. Here, we show that these microtubules are actually inside the nuclear envelope.

PMID:
15573098
DOI:
10.1038/ncb1200
[Indexed for MEDLINE]

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