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Dev Cell. 2004 Dec;7(6):783-93.

The versatile roles of "axon guidance" cues in tissue morphogenesis.

Author information

1
Department of Molecular, Cell, and Developmental Biology, University of California, Santa Cruz, Santa Cruz, CA 95064 USA. hinck@biology.ucsc.edu

Abstract

The Netrin, Slit, Semaphorin, and Ephrin families of secreted proteins were originally characterized in the nervous system as guidance cues for axons; however, recent studies demonstrate that many members of these families contribute to the development of a variety of organs. Here, the current knowledge of their roles is discussed with a focus on four tissues: lung, mammary, cardiovascular, and kidney. While many studies indicate a role for "axon guidance" cues in regulating cell-cell and cell-extracellular matrix (ECM) interactions during organogenesis, there is accumulating evidence that they also contribute to tissue development by regulating the transcription and translation of genes encoding key morphogenetic factors.

PMID:
15572123
DOI:
10.1016/j.devcel.2004.11.002
[Indexed for MEDLINE]
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