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Biochim Biophys Acta. 2004 Nov 29;1695(1-3):209-13.

Productive RUPture: activation of transcription factors by proteasomal processing.

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  • 1Department of Molecular Cell Biology, Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany.


Proteasomes usually degrade proteins completely into small peptides. In a few cases, however, proteasomal degradation rather results in protein processing, thereby yielding proteins of different biological activity. This process, termed "regulated ubiquitin/proteasome-dependent processing" or RUP, is essential for the function of certain transcription factors and crucial for their regulation. Examples are proteins of the mammalian NF-kappaB family and the yeast proteins SPT23 and MGA2. In this review, we summarize the available data and suggest a mechanistic model for proteasomal processing.

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