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Neuroreport. 2004 Dec 3;15(17):2647-50.

Restoration of axotomy-induced PACAP gene induction in SCID mice with CD4+ T-lymphocytes.

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University of California at Los Angeles, 760 Westwood Plaza, NPI 68-225, Los Angeles, CA 90024, USA.


PACAP is a neuropeptide with putative neuroprotective, regenerative, and immunomodulatory actions. PACAP mRNA is up-regulated in motor neurons following facial nerve axotomy in wild type, but not immunodeficient SCID mice. Because CD4+ lymphocytes appear to be neuroprotective in facial nerve and other injury models, we studied PACAP gene expression in SCID mice preinfused with CD4+ enriched splenocytes. Whereas the mean number of PACAP hybridizing neurons after axotomy was reduced by 75% in uninfused SCID mice, infusion of CD4+ enriched splenocytes restored the number to a value not significantly different than controls. The CD4+ cell-dependent induction of PACAP in motor neurons may thus be a factor in the cascade of events triggered by immune cells that ultimately lead to nerve regeneration.

[Indexed for MEDLINE]

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