Format

Send to

Choose Destination
Annu Rev Genet. 2004;38:347-63.

Genetic models in pathogenesis.

Author information

1
Centre d'Immunologie de Marseille-Luminy, INSERM/CNRS/Universite de la Mediterranee, Case 906, 13288 Marseille Cedex 09, France. pradel@ciml.univ-mrs.fr

Abstract

To decipher the complexity of host-pathogen interactions the widest possible range of model hosts and of analytical methods is required. As some virulence mechanisms and certain host responses have been conserved throughout evolution, even simple organisms can be used as model hosts to help our understanding of infectious diseases. The availability of molecular genetic tools and a cooperative community of researchers are pivotal to the emergence of model systems. In this review, we first summarize the genetic screens that can be used to identify pathogen virulence factors, then we present a comparative overview of existing or emerging genetically tractable host models.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Atypon
Loading ...
Support Center