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Res Microbiol. 2004 Dec;155(10):803-10.

Dissecting the twin-arginine translocation pathway using genome-wide analysis.

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Department of Plant Pathology, Cornell University, Ithaca, NY 14853, USA.


A recently discovered route for protein export, known as the twin-arginine translocation (Tat) pathway, has received much attention owing to several atypical characteristics that distinguish it from other transport mechanisms. For instance, recent evidence has clearly established that this pathway only transports folded polypeptides. Moreover, several studies have demonstrated a vital role for the Tat pathway in bacterial pathogenesis. In this review, we discuss genomic approaches that have been employed to determine the prevalence and capacity of the Tat system and how the information generated from these approaches is helping to connect Tat transport to bacterial physiology and virulence.

[Indexed for MEDLINE]

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