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Immunogenetics. 2005 Jan;56(10):754-9. Epub 2004 Nov 24.

Characterization of natural peptide ligands from HLA-DP2: new insights into HLA-DP peptide-binding motifs.

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Departamento de Microbiología II, Facultad de Farmacia, Universidad Complutense de Madrid, 28040, Madrid, Spain.


Although natural peptide ligands of HLA-DR and HLA-DQ molecules have been extensively studied, information about peptides naturally bound to HLA-DP is limited. Here we describe HLA-DP2 peptide ligands corresponding to 24 different source proteins that were identified by peptide pool elution and mass spectrometry sequencing from HLA-DP2 molecules expressed on EBV-LCLs. Sequencing analysis led to the identification of both promiscuous and allele-specific peptides. Moreover, the alignment of the natural ligands for HLA-DP2 described here, combined with previous results from our group and others concerning HLA-DP2 antigen presentation and HLA-DP molecular modelling, provide a better understanding of HLA-DP2 peptide-binding motifs.

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