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Braz J Infect Dis. 2004 Aug;8(4):328-30. Epub 2004 Nov 19.

Deficiency of the eighth component of complement associated with recurrent meningococcal meningitis--case report and literature review.

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Internal Medicine Department, Nossa Senhora da Conceição Hospital, Porto Alegre, Rio Grande do Sul, Brazil.


The authors report a case of deficiency of the eighth component of complement in a young adult with a history of three episodes of meningitis; one of them proved to be meningococcal. The literature was reviewed and meningitis due to Neisseria meningitidis strains causing disease in complement-deficient and complement-sufficient patients was demonstrated. Meningococcal disease may be the first manifestation of complement deficiency; screening for complement function must be considered for those with invasive meningococcal disease, with posterior evaluation of the components of the terminal pathway of complement.

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