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Nat Prod Rep. 2004 Dec;21(6):695-721. Epub 2004 Oct 28.

Biosynthesis of pantothenate.

Author information

1
University Chemical Laboratory, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK. mew23@cantab.net

Abstract

Pantothenate is an essential metabolite for all biological systems, however, the biosynthetic pathway is limited to plants, eubacteria and archaea. This suggests that the pathway is a strong candidate for the discovery of novel antibiotic and herbicidal compounds. The enzymology of this short pathway in both bacteria and plants is discussed in detail. In addition a short survey of studies of the whole pathway, and a discussion of both the metabolism and the transport of pantothenate are included.

PMID:
15565250
DOI:
10.1039/b316419p
[Indexed for MEDLINE]

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