Format

Send to

Choose Destination
See comment in PubMed Commons below
PLoS Biol. 2004 Dec;2(12):e427. Epub 2004 Nov 30.

A transcriptional profile of aging in the human kidney.

Author information

1
Division of Nephrology, Stanford University Medical Center Stanford, California, USA.

Abstract

In this study, we found 985 genes that change expression in the cortex and the medulla of the kidney with age. Some of the genes whose transcripts increase in abundance with age are known to be specifically expressed in immune cells, suggesting that immune surveillance or inflammation increases with age. The age-regulated genes show a similar aging profile in the cortex and the medulla, suggesting a common underlying mechanism for aging. Expression profiles of these age-regulated genes mark not only age, but also the relative health and physiology of the kidney in older individuals. Finally, the set of aging-regulated kidney genes suggests specific mechanisms and pathways that may play a role in kidney degeneration with age.

PMID:
15562319
PMCID:
PMC532391
DOI:
10.1371/journal.pbio.0020427
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Public Library of Science Icon for PubMed Central
    Loading ...
    Support Center