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Diabetologia. 2004 Nov;47(11):1953-6. Epub 2004 Nov 19.

Smoking is associated with an increased risk of type 2 diabetes but a decreased risk of autoimmune diabetes in adults: an 11-year follow-up of incidence of diabetes in the Nord-Trøndelag study.

Author information

1
Division of Epidemiology, Stockholm Centre of Public Health and Department of Epidemiology, Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden.

Abstract

AIMS/HYPOTHESIS:

We compared the association between smoking habits and later occurrence of type 2 diabetes on the one hand and between smoking and diabetes with autoimmunity on the other hand.

METHODS:

We used data from a prospective study of 11-year cumulative incidence of diabetes in the Nord-Trøndelag Health Survey.

RESULTS:

Confirming previous reports, heavy smoking (>/=20 cigarettes per day) carried an increased relative risk (RR) of type 2 diabetes (n=738, RR=1.64, 95% CI: 1.12-2.39). In contrast, smoking reduced the risk of latent autoimmune diabetes in adults (LADA) and of traditional type 1 diabetes (LADA n= 81, RR=0.25, 95% CI: 0.11-0.60; type 1 diabetes, n=18, RR=0.17, 95% CI: 0.04-0.73).

CONCLUSIONS/INTERPRETATIONS:

The results indicate that nicotine influences autoimmune processes in human diabetes.

PMID:
15558231
DOI:
10.1007/s00125-004-1554-9
[Indexed for MEDLINE]

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