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Neurology. 2004 Nov 23;63(10):1966-7.

CSF characteristics in early-onset multiple sclerosis.

Author information

1
Department of Pediatrics and Pediatric Neurology, Georg-August-University Goettingen, Robert-Koch-Strasse 40, 37075 Goettingen, Germany. dpohl@med.uni-goettingen.de

Abstract

The authors studied CSF characteristics in 136 patients with multiple sclerosis (MS) with a disease onset before age 16. In the initial diagnostic lumbar puncture, CSF-pleocytosis was observed in 66%, blood-CSF barrier dysfunction in 13%, and oligoclonal IgG in 92% of the early-onset MS (EOMS) patients. CSF oligoclonal IgG supports the early diagnosis of MS in childhood with a sensitivity similar to adult-onset MS.

PMID:
15557527
[Indexed for MEDLINE]

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