Subthalamic nucleus deep brain stimulation in Parkinson disease patients over age 70 years

H Russmann; J Ghika; J-G Villemure; B Robert; J Bogousslavsky; P R Burkhard; F J G Vingerhoets

doi:10.1212/01.wnl.0000144198.26309.d8

Subthalamic nucleus deep brain stimulation in Parkinson disease patients over age 70 years

Neurology. 2004 Nov 23;63(10):1952-4. doi: 10.1212/01.wnl.0000144198.26309.d8.

Authors

H Russmann¹, J Ghika, J-G Villemure, B Robert, J Bogousslavsky, P R Burkhard, F J G Vingerhoets

Affiliation

¹ Department of Neurology, University Hospital CHUV, Lausanne, Switzerland.

PMID: 15557522
DOI: 10.1212/01.wnl.0000144198.26309.d8

Abstract

The effects of subthalamic nucleus deep brain stimulation were studied in 52 consecutive patients (13 over age 70, 15 under age 60, 24 age 60 to 70). All groups had improvement of motor fluctuations and dyskinesia. Patients over age 70 had worsening of Unified Parkinson's Disease Rating Scale motor scores on medication, despite less medication reduction. Their activities of daily living and axial subscores worsened, particularly in those with preoperative gait difficulties.

Publication types

Comparative Study
Evaluation Study
Research Support, Non-U.S. Gov't

MeSH terms

Age Factors
Aged
Aged, 80 and over
Antiparkinson Agents / therapeutic use
Cohort Studies
Combined Modality Therapy
Deep Brain Stimulation* / adverse effects
Deep Brain Stimulation* / methods
Deep Brain Stimulation* / statistics & numerical data
Dopamine Agonists / therapeutic use
Female
Humans
Levodopa / therapeutic use
Male
Middle Aged
Parkinson Disease / drug therapy
Parkinson Disease / therapy*
Risk Assessment
Treatment Outcome

Substances

Antiparkinson Agents
Dopamine Agonists
Levodopa