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Neurology. 2004 Nov 23;63(10):1936-8.

A novel candidate region for ALS on chromosome 14q11.2.

Author information

1
Department of Clinical Neurological Sciences, Royal College of Surgeons in Ireland. mattgreenway@rcsi.ie

Abstract

Sequence variations with biologic effect in ALS have been identified in the gene for vascular endothelial growth factor (VEGF). The gene for a related protein, angiogenin, lies on chromosome 14q11.2. Analysis of the angiogenin (ANG) gene in the authors' population has demonstrated a significant allelic association with the rs11701 single nucleotide polymorphism (SNP) and identified a novel mutation in two individuals with sporadic ALS that potentially inhibits angiogenin function. These observations propose a candidate region for ALS on chromosome 14q11.2 and suggest that other genes with similar function to VEGF may be important in the pathogenesis of ALS.

PMID:
15557516
[Indexed for MEDLINE]

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