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Curr Opin Microbiol. 2004 Dec;7(6):638-46.

Transcriptional networks: reverse-engineering gene regulation on a global scale.

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  • 1Banting and Best Department of Medical Research, University of Toronto, 112 College Street, Room 307, Toronto, Ontario M5G 1L6, Canada.


A major objective in post-genome research is to fully understand the transcriptional control of each gene and the targets of each transcription factor. In yeast, large-scale experimental and computational approaches have been applied to identify co-regulated genes, cis regulatory elements, and transcription factor DNA binding sites in vivo. Methods for modeling and predicting system behavior, and for reconciling discrepancies among data types, are being explored. The results indicate that a complete and comprehensive yeast transcriptional network will ultimately be achieved.

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