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Int J Antimicrob Agents. 2004 Dec;24(6):562-6.

Risk factors and mortality associated with Clostridium difficile-associated diarrhoea at a VA hospital.

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Pharmacy Services, Edward Hines Jr. VA Hospital, Fifth Avenue and Roosevelt Road, Building 200, Room 1243, Hines, IL 60141, USA.


The objective of this study was to evaluate the risk of certain patient co-morbidities and antibiotics in the development of Clostridium difficile-associated diarrhoea (CDAD). Hospitalized patients developing CDAD during a specified period were compared with a cohort of patients, matched by age, without a diagnosis of CDAD, who were hospitalized during the same time period. Data collection included demographics, hospital ward, co-morbid conditions, antibiotics received, and mortality. Gender and age were similar in both groups. Co-morbid conditions significantly associated with the case group included cancer and COPD. The most commonly prescribed antibiotics in the case versus control group included levofloxacin, intravenous vancomycin, clindamycin, and piperacillin/tazobactam. The case group was associated with a higher mortality rate.

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