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Microbes Infect. 2004 Nov;6(14):1333-8.

The role of TRAF6 in signal transduction and the immune response.

Author information

1
Abramson Family Cancer Research Institute, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, 421 Curie Blvd., Room 308, Philadelphia, PA 19104, USA.

Abstract

Signals from the IL-1 receptor (IL-1R)/Toll-like receptor (TLR) family and TNF receptor (TNFR) superfamily are critical for regulating the function of antigen-presenting cells such as dendritic cells (DCs). It has been revealed that TNF receptor-associated factor 6 (TRAF6), a signaling adapter molecule common to the IL-1R/TLR family and TNFR superfamily, is important not only for DC maturation, cytokine production, and T cell stimulatory capacity of DCs in response to TLR ligands (e.g. lipopolysaccharide) or CD40 ligand, but also for the homeostasis of splenic DC subsets.

PMID:
15555541
DOI:
10.1016/j.micinf.2004.09.001
[Indexed for MEDLINE]

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