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Phytother Res. 2004 Oct;18(10):841-4.

In vitro anti-tyrosinase activity of 5-(hydroxymethyl)-2-furfural isolated from Dictyophora indusiata.

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1
Applied Biotechnology Laboratory, Department of Biology, Kongju National University, Kongju, Republic of Korea.

Abstract

The inhibition of mushroom tyrosinase by methanolic extract of Dictyophora indusiata was evaluated and the bioactive component was characterized and identified as 5-(hydroxymethyl)-2-furfural (HMF) by chromatographic and spectroscopic means. Kinetic studies revealed it to be a noncompetitive inhibitor for the oxidation of L-DOPA. On the basis of these findings some related analogues were also tested for their anti-tyrosinase activity, in order to gain more insight into structure and activity relationship among these heterocyclic compounds.

PMID:
15551389
DOI:
10.1002/ptr.1428
[Indexed for MEDLINE]
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