Format

Send to

Choose Destination
Nat Rev Microbiol. 2004 Dec;2(12):933-45.

The evolution of chronic infection strategies in the alpha-proteobacteria.

Author information

1
Laboratory of Plant Microbe Interactions, CNRS-INRA, BP27, 31326 Castanet-Tolosan Cedex, France.

Abstract

Many of the alpha-proteobacteria establish long-term, often chronic, interactions with higher eukaryotes. These interactions range from pericellular colonization through facultative intracellular multiplication to obligate intracellular lifestyles. A common feature in this wide range of interactions is modulation of host-cell proliferation, which sometimes leads to the formation of tumour-like structures in which the bacteria can grow. Comparative genome analyses reveal genome reduction by gene loss in the intracellular alpha-proteobacterial lineages, and genome expansion by gene duplication and horizontal gene transfer in the free-living species. In this review, we discuss alpha-proteobacterial genome evolution and highlight strategies and mechanisms used by these bacteria to infect and multiply in eukaryotic cells.

PMID:
15550939
DOI:
10.1038/nrmicro1044
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Nature Publishing Group
Loading ...
Support Center