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Nature. 2004 Nov 18;432(7015):332-7.

Stromal fibroblasts in cancer initiation and progression.

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1
Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA.

Abstract

It is widely accepted that the development of carcinoma--the most common form of human cancer--is due to the accumulation of somatic mutations in epithelial cells. The behaviour of carcinomas is also influenced by the tumour microenvironment, which includes extracellular matrix, blood vasculature, inflammatory cells and fibroblasts. Recent studies reveal that fibroblasts have a more profound influence on the development and progression of carcinomas than was previously appreciated. These new findings have important therapeutic implications.

PMID:
15549095
PMCID:
PMC3050735
DOI:
10.1038/nature03096
[Indexed for MEDLINE]
Free PMC Article
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