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Org Lett. 2004 Nov 25;6(24):4575-7.

Convenient catalytic, enantioselective conjugate reduction of nitroalkenes using CuF2.

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1
Laboratorium für Organische Chemie, ETH Zürich, ETH Hönggerberg, HCI, H335, CH-8093 Zürich, Switzerland.

Abstract

We document the use of a new catalyst system for the enantioselective conjugate reduction of nitroalkenes utilizing commercially available CuF(2) and the bis-phosphine JOSIPHOS as a ligand. This new protocol not only facilitates ready access to a variety of optically active nitroalkanes, but the results provide also new insight into copper-catalyzed reactions. [reaction: see text]

PMID:
15548079
DOI:
10.1021/ol048035h
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