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Bioorg Med Chem Lett. 2004 Dec 20;14(24):6107-11.

The synthesis and evaluation of [2.2.1]-bicycloazahydantoins as androgen receptor antagonists.

Author information

1
Department of Oncology Chemistry, Bristol-Myers Squibb Pharmaceutical Research Institute, PO Box 4000, Princeton, NJ 08543-4000, USA. aaron.balog@bms.com

Abstract

A novel series of [2.2.1]-azahydantoins has been designed and synthesized in an enantiospecific manner. The ability of these compounds to act as antagonists to the androgen receptor was investigated and several were found to have potent activity in vitro.

PMID:
15546739
DOI:
10.1016/j.bmcl.2004.09.049
[Indexed for MEDLINE]

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